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Study shows that Ketamine Infusion Therapy is on par with ECT as a therapy for treatment-resistant major depression

A new study published in the New England Journal of Medicine found that ketamine was as effective as ECT. The clinical study looked at the effects of ketamine infusion therapy versus electroconvulsive therapy (ECT) in treating patients with treatment-resistant major depression.1

Over half (55.4%) of the patients treated with ketamine infusion therapy showed a positive response, compared to 41.2% in the ECT group. This suggests that ketamine may offer considerable benefits for patients dealing with treatment-resistant depression.

In addition, while ECT was linked with a temporary decrease in memory recall, this was not a significant issue with ketamine. Patients reported that improvement in their quality of life was comparable between the two groups, which means that ketamine’s effectiveness is on par with ECT but potentially with fewer cognitive side effects.

The study concluded that ketamine could offer a promising alternative to ECT for patients dealing with treatment-resistant major depression. This information could be helpful to patients talking to their doctor about alternative treatment options for treatment-resistant major depression. 

1. https://www.nejm.org/doi/full/10.1056/NEJMoa2302399

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Iris Mejia, RN

Iris Mejia, RN, is a registered nurse with a bachelor’s degree in nursing from the University of Hawaii Maui College. With 21 years of experience as a Labor and Delivery nurse, she developed a keen interest in mental health nursing. Her firsthand experience with ketamine infusion therapy led her to pursue her passion in this field.

Iris is dedicated to helping patients achieve their optimal well-being through compassionate care and evidence-based practices.

Outside of work, Iris enjoys practicing yoga, traveling, and spending quality time with her family.

Susan DeRobertis,
BSN, BSN, PMHRN-BC

Susan DeRobertis, BSN, BSN, PMHRN-BC, is a board-certified Psychiatric Mental Health Registered Nurse and holds a Bachelor of Science in Nursing from Cal State Fullerton.

Susan’s commitment to mental health and wellness is driven by a deep understanding of the challenges faced by those struggling with mood disorders. Having witnessed firsthand the limitations of traditional therapies for depression, anxiety, PTSD, and other mood and chronic pain disorders, she is an advocate of ketamine infusion therapy as a transformative treatment option. Susan is passionate about supporting individuals and their families through their mental health journeys and continues to be excited when she sees firsthand the positive changes that ketamine therapy can bring.

Over the past decade, Susan has dedicated herself to providing care at the Mental Health and Wellness Institute at Mission Hospital Laguna Beach. She is also a nursing instructor at the University of California, Irvine.

Beyond her professional accomplishments, Susan is a devoted mother, a talented musician, and an avid live music fan. She finds joy in spending quality time with her daughters, traveling, and attending concerts.