Ketamine Administration Routes and Why it Matters

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At Ketamine Wellness Clinic of Orange County, we only offer patients intravenous (IV) ketamine. Intranasal and oral ketamine are not absorbed directly into the bloodstream at the time of administration which means that patients only see a fraction of the effect of the dose of ketamine administered.   

When patients receive intravenous (IV) ketamine therapy, 100% of the medication enters systemic circulation. There are a handful of clinics in the United States that offer intranasal esketamine and/or oral ketamine. However, both intranasal and oral ketamine are not circulated directly into the bloodstream at the time of administration resulting in patients only seeing a fraction of the effect of the dose of ketamine administered. For example, with oral therapy the medication needs to go through both the stomach and liver, leaving only a small percentage of the drug to reach the brain.

The bioavailability of ketamine when administered intravenously is 100%. Our physicians are able to deliver a very precise dose to patients knowing that 100% of the medication will be made available to the patient’s brain for therapy.

This is why the physicians at Ketamine Wellness Clinic of Orange County believe so strongly in providing patients the option of ketamine therapy via IV. It gives the patient the best chance to have the maximum benefits of ketamine therapy.

 

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